Regenerates from three lines of stem cells Understanding how the hydra regenerates its entire nervous system, for example, could help us better understand neurodegenerative diseases in humans. The data set will help researchers understand regulatory gene networks in place early in evolution that are shared among many animals, including humans, Siebert said. The study gives developmental biologists a high-resolution map of the three stem cell developmental lineages in hydra. "The beauty of single-cell sequencing and why this is such a big deal for developmental biologists is that we can actually capture the genes that are expressed as cells differentiate from stem cells into their different cell types," Juliano said. Celina Juliano, assistant professor in the UC Davis Department of Molecular and Cellular Biology, project scientist Stefan Siebert and colleagues including Jeff Farrell, a postdoctoral researcher at Harvard University, sequenced the RNA transcripts of 25,000 single hydra cells to follow the genetic trajectory of nearly all differentiated cell types.
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